Basic and clinical immunology – 3027. Group of immune factors studied in relation to early development of allergic symptoms in an Indian subpopulation at one year of age
نویسندگان
چکیده
Methods Healthy term newborns in families with h/o allergy were enrolled after informed consent at the time of birth. This Indian birth cohort of 99 babies with family history of allergy (75) and no history of allergy (24) was studied for minimum of 1.5 years for development of allergies with evaluation of chemokine receptors (CXCR3, CCR5, CCR3, CCR4, CCR8). Markers of Th1 (IFNg, IL12p40) and Th2 (IL4, IL13) responses were also compared. Expression of molecules was studied using semi quantitative RT-PCR. The study was approved by the local Medical ethics review board.
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